SPIVAK CRO SERVICES

Bio-medical research, Pre-clinical & In-vivo models establishing; Pharmacokinetics & Pharmacodynamics; Toxicological and Efficacy services. Development of novel drugs candidate with a focusing on CNS, Oncology, Urology, Dermatology, Cardiology, Pulmonology and Inflammatory. Respiratory, Ophthalmic, Urological, Neurological and Metabolic diseases; Clear understanding of IACUC; Establishment of high-quality feasibility studies. • Various CNS & Ophthalmic microsurgery techniques & models: Middle Cerebral Artery permanent/ temporary occlusion; Brain implantation techniques; Traumatic Spinal Cord Injury; Optic Nerve Axotomy; Episcleral vein occlusion, Retinal Ischemia Reperfusion, and Retrograde RGC labeling. • Abdominal surgery techniques & metabolic models: Unilateral Ureter Obstruction; 5/6 Nephrectomy; Acute Renal Failure; Chronic Renal Failure; Unilateral Nephrectomy/Renal Ischemia Reperfusion; Bile Duct Ligation; Micro osmotic pump implantation. • Micro injections techniques: Intranasal; Intratracheal; Intravitreal; Retro-orbital sinus; Retro-bulbar; Sub Conjunctival; Portal Vein; Brain Intraventricular; Intrathecal; Hydrodynamic high-pressure. • Rodent cancer models: for screening tests of new small molecule/drug discovery projects, tumor cells implantations; metastatic/host tumor models. • Research experience in small animal dissections & sampling procedures: blood vessel cannulation; intra cardiac/tracheal/portal vein perfusion; blood collection, tissues micro dissection & harvesting, organs sampling preparations for complete histology, molecular and other analyses • Research efforts and physiological/behavioral monitoring systems application; invasive and non-invasive monitoring techniques • Digital image preparation and analysis.