System Biosciences

At SBI, we are a highly-motivated team committed to converting new technologies into unique and innovative cell and molecular biology products and services, such as tools for exosome research, vector delivery technologies, microRNA research, and genome engineering tools. We pride ourselves on being among the first to market with many of our product families, as well as our dedication to the continuing improvement of existing products, our high-quality manufacturing and execution of services, and our deep scientific expertise. Product and Service Focus Areas: Exosome Research Tools: • Isolate exosomes with ExoQuick and ExoQuick-TC • Exo-Flow- Immunopurify exosomes on magentic beads and anlayze by FACS • Culture cells in exosome-depleted FBS • Verify exosome recovery with antibodies Vector Technologies: • Powerful lentivector systems • One-step transfection piggyBac transposons • Single-copy gene additions with phiC31 integrase vectors • Sustained expression without integration with Minicircle DNA plasmids Genome Engineering: • RNA-guided Cas9 SmartNuclease system • Fast and efficient mutation correction / gene editing • HR donor vectors for knock-in, knock-out & tagging • High-throughput, targeted integration with PinPoint technology Non-coding RNA: • LncRNA qPCR profiling kits • miRNome and OncoMir qPCR profiling systems • Lenti-miR Precursor clone libraries – arrayed and pooled • miRZip anti-miR clones for stable miRNA inhibition Exo-NGS Custom Service: • Provide serum, tissue culture media, or other patient biofluids to SBI • SBI isolates exosomes, purifies RNA and generates high quality NGS libraries • Sequencing performed using Illumina MiSeq and HiSeq platforms • Comprehensive data analysis, including generation of heat maps and top hits, provided • NGS data loaded onto a custom UCSC Genome Browser for convenient viewing