Chloe Jonas
About
Chloe Jonas is from Philadelphia, Pennsylvania, United States. Chloe works in the following industries: "Biotechnology Research". Chloe is currently Associate Scientist at Chimeron Bio, located in Philadelphia, Pennsylvania, United States. In Chloe's previous role as a Associate Scientist at Amicus Therapeutics, Chloe worked in Philadelphia, Pennsylvania, United States until Feb 2022. Prior to joining Amicus Therapeutics, Chloe was a Bench Scientist - Upstream Manufacturing Operations at GSK and held the position of Bench Scientist - Upstream Manufacturing Operations at King of Prussia, PA. Prior to that, Chloe was a Cell and Gene Therapy Development Co-Op at WuXi AppTec, based in Philadelphia, PA from Apr 2018 to Sep 2018. Chloe started working as Customer Quality Engineering Co-Op at Johnson & Johnson: Animas in Wayne, PA in Sep 2016. From Sep 2015 to Mar 2016, Chloe was Research Student Co-Op at Lankenau Institute for Medical Research, based in Wynnewood, PA. Prior to that, Chloe was a Product Development Intern at Integra Life Sciences , based in Plainsboro, NJ from Jun 2015 to Aug 2015.
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Chloe Jonas's current jobs
Chloe Jonas's past jobs
-Experienced in molecular cloning techniques such as Golden Gate, Gibson, and SLIC cloning to create transgene libraries for gene therapy pipeline programs in pre-clinical setting -Developed and optimized in vitro transgene screening platform to evaluate large transgene technology for AAV-mediated gene therapy. Utilized techniques such as transfections, western blotting, and reporter-based assays -Designed DNA oligo primers using Benchling software for creation of DNA constructs and Sanger sequencing. -Prepared plasmid DNA from bacterial culture at mini, maxi, and giga prep scale for in vitro expression screening, AAV production, and in vivo proof of concept studies -Managed the cataloguing and organization of unit's transgene libraries to maximize efficiency -Presented experimental data and new prospective technologies to cross-functional teams -Formulated detailed protocols for documentation in electronic lab notebooks
-Supported the manufacture of investigational biopharmaceutical molecules for use in early phase clinical trials -Prepared media for mammalian cell culture, in 50 L to 2,000 L bioreactors, under cGMP regulatory conditions -Documented work performed via media forms, batch records, and electronic systems
- Programmed an automated perfusion protocol for the remote operation/monitoring of a cell expansion system - Conducted experiments to evaluate the efficacy of processes for T cell growth and expansion in a controlled environment - Implemented an established protocol for the department going forward to use in the growth of cell therapies
- Created routine reports in order to investigate product failure trends and determine root causes - Visualized data for presentations on complaint lifecycle to ensure timely reporting to proper regulatory authorities - Investigated returned consumer products to generate complaint data on device failures and malfunctions - Trained two new co-ops and created a manual of procedures to effectively transfer responsibilities
- Performed invasion assays with hematopoietic and tumor cell lines to determine efficacy of different compounds in combatting polyamine synthesis and transport in cancerous cells - Developed a new protocol for invasion assays with tumor cell lines to promote consistency between experiments - Maintained cell lines using standard aseptic techniques
- Designed a new concept for a dural sealant applicator to create a more efficient and user-friendly device - Researched competitor products to understand clinical applications and develop a technical competitive landscape - Performed testing on surgical headlights to improve quality of light emitted