Jikrul Islam
About
Jikrul Islam is from 孟加拉. Jikrul works in the following industries: "生物技术". Jikrul is currently Senior Scientific Officer, Gr-II and Head of Quality Control at Globe Biotech Limited, located in Plot# 3Ka (new), Tejgaon I/A Dhaka-1208, Bangladesh. In Jikrul's previous role as a Senior Scientific Officer, Gr-I and In-Charge of Analytical Development at Globe Biotech Limited, Jikrul worked in Plot # 3/Ka (New), Tejgoan I/A Dhaka-1208, Bangladesh until May 2021. Prior to joining Globe Biotech Limited, Jikrul was a Scientific Officer, Gr-II at Globe Biotech Limited and held the position of Scientific Officer, Gr-II at Dhaka, Bangladesh. Prior to that, Jikrul was a Scientific officer, Gr-I at Globe Biotech Limited at Globe Biotech Limited, based in Plot # 3/Ka (New), Tejgoan I/A Dhaka-1208, Bangladesh from Feb 2016 to May 2017.
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Jikrul Islam's current jobs
- COVID-19 vaccine candidate development and characterization: Lead and execute the characterization of mRNA-based vaccine candidate. - Analysis of Recombinant protein and monoclonal antibody: Certification of vector, expression construct, clone, intermediates, master cell bank and working cell bank, physiochemical and physiological characterization of recombinant protein and monoclonal antibody. - Trainer of different types of QC analysis method such as: Next generation sequencing (NGS), surface plasmon resonance (SPR), in-vitro cell proliferation assays, real-time PCR (qPCR), SDS PAGE, western blot, 2-D gel electrophoresis, agarose gel electrophoresis, urea PAGE, ELISA, dot blot. - SARS COV-2 detection kit: Responsible for RT-PCR based detection kit development, evaluation (specificity, accuracy, sensitivity and cross-reactivity) and technology transfer.
Jikrul Islam's past jobs
Analytical Development, R&D Laboratory - Analytical method development and validation - Analysis and certification of vector, expression construct, clone, intermediates, drug substance and drug product - Physio-chemical and physiological characterization of drug substance and drug product - Stability study of clone, intermediates, drug substance and drug product - Development of Quality Management System - Have advanced level knowledge about ICH, US-FDA, EU and WHO regulation - Responsible for Human Exome analysis with Next generation sequencing technology using Ion S5 and Ion S5 XL system. - Responsible for different types of primer designing - Responsible for primer, short oligonucleotide (DNA, RNA) and SiRNA synthesis with AKTA Oligopilot 10 chain reaction technology. - Responsible for primer, short oligonucleotide (DNA, RNA) and SiRNA purification with AKTA PURE or AKTA AVANT purification technology. - Responsible for DNA sequencing of microbial isolates and also different types of expression contract using ABI 3500 technology. - Conducting the protein-protein analysis with surface plasmon resonance technology using Biacore T200. - Perform the plasmid copy number, mRNA expression level, presence-absence and melt curve analysis with QuantStudio 12 K Flex real-time PCR system. - Responsible for protein identification and quantification analysis: Dot Blot, 2-D gel electrophoresis and ELISA.
Analytical Development, R&D Laboratory - Analytical method development and validation - Analysis and certification of vector, expression construct, clone, intermediates, drug substance and drug product - Physio-chemical and physiological characterization of drug substance and drug product - Stability study of clone, intermediates, drug substance and drug product - Development of Quality Management System - Have advanced level knowledge about ICH, US-FDA, EU and WHO regulation - Responsible for Human Exome analysis with Next generation sequencing technology using Ion S5 and Ion S5 XL system. - Responsible for different types of primer designing - Responsible for primer, short oligonucleotide (DNA, RNA) and SiRNA synthesis with AKTA Oligopilot 10 chain reaction technology. - Responsible for primer, short oligonucleotide (DNA, RNA) and SiRNA purification with AKTA PURE or AKTA AVANT purification technology. - Responsible for DNA sequencing of microbial isolates and also different types of expression contract using ABI 3500 technology. - Conducting the protein-protein analysis with surface plasmon resonance technology using Biacore T200. - Perform the plasmid copy number, mRNA expression level, presence-absence and melt curve analysis with QuantStudio 12 K Flex real-time PCR system. - Responsible for protein identification and quantification analysis: Dot Blot, 2-D gel electrophoresis and ELISA.
Analytical Development and Quality Operations, R&D Laboratory - Standard Operating Procedure (SOP) Preparations - Compliance System Development - Instrument Qualification, Calibration & Validation - Analytical Method Development & Validation - Environmental Microbes Monitoring in Whole Lab Facilities - Relative and Absolute Quantification of DNA by Real-Time PCR (qPCR) - DNA Restriction Digestion & Ligation - Reverse Transcription Polymerase Chain Reaction (RT-PCR) - DNA Sequencing - SDS PAGE & Western Blot Analysis - PCR & Agarose Gel Electrophoresis - DNA & Protein Quantification - Master Cell Bank Characterization - Working Cell Bank Characterization - Good knowledge About cGMP and cGLP