Madhusoodanan Urulangodi
About
Madhusoodanan Urulangodi is from Thiruvananthapuram Taluk, Kerala, India. Madhusoodanan works in the following industries: "Research". Madhusoodanan is currently Assistant Professor at Sree Chitra Tirunal Institute for Medical Sciences and Technology, located in Thiruvananthapuram Area, India. In Madhusoodanan's previous role as a Research Scientist-Molecular Oncology at MVR Cancer Centre & Research Institute, Madhusoodanan worked in Calicut Area, India until Sep 2017. Prior to joining MVR Cancer Centre & Research Institute, Madhusoodanan was a Postdoctoral Fellow at IFOM - The FIRC Institute of Molecular Oncology Foundation, Milan, Italy. and held the position of Postdoctoral Fellow at Milan Area, Italy. Prior to that, Madhusoodanan was a Visiting Fellow at NCBR, Masaryk University, Brno, Czech Republic., based in Brno, Czech Republic from Feb 2010 to Apr 2010. Madhusoodanan started working as PhD at Indian Institute of Science in Bengaluru Area, India in Jan 2003.
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Madhusoodanan Urulangodi's current jobs
Madhusoodanan Urulangodi's past jobs
“Regulatory mechanisms coordinating replication integrity and intra-S repair in Saccharomyces cerevisiae”. In addition to general genetic, biochemical and molecular biology approaches, the Genome-wide studies were used extensively in my research. This includes ChIP-on-chip, and ChIP-qPCR techniques that combine chromatin immunoprecipitation (ChIP) with DNA microarray (chip), sequencing, or quantitative PCR to investigate interactions between proteins and DNA in vivo genome-wide. Two dimensional (2-D) agarose gel electrophoresis to analyze the molecular nature of replication and recombination intermediates under DNA damaging conditions and visualization of such structures using electron microscopy. The high-throughput Synthetic Genetic Array (SGA) to study synthetic lethal and synthetic sick genetic interactions using Saccharomyces cerevisiae. This will provide functional information of the gene of interest and the interacting genes. Conferences attended. 1. 8th Young Investigator Meeting (YIM) at Manesar, Delhi, INDIA. February 27th to March 2nd, 2016. Poster presentation. 2. 2nd Chromosome stability meeting. December 14-18, 2014. JNCASR, Bangalore, India. Oral presentation. 3. Benzon Symposium NO 60. Nuclear regulation by ubiquitin. August 18-21, 2014. Copenhagen, Denmark. Poster presentation. 4. Keystone Symposia Conference (X6: Genomic Instability and DNA Repair). March 3-8, 20 13, at the Fairmont Banff Springs, Banff, Alberta, Canada. Poster presentation.
To carryout ongoing collaborative project in Dr.Lumir Krejciʼs laboratory.
Supervisor: Prof. Desirazu N Rao, Department of Biochemistry, IISc, Bangalore. Title: “Functional Analysis of Unique Motifs in Dimeric EcoP15I DNA Methyltransferase”. Major findings: 1. Identified a PD(X)n(D/E)XK-like motif in EcoP15I DNA methyltransferase and characterized biochemically. 2. Identified residues involved in dimerisation of EcoP15I DNA methyltransferase and showed that dimerisation is important for its enzyme activity. 3. Identified the roles played by the N- and C-terminal domains of EcoP15I in dimerisation, protein folding and stability.