Matthew Troese
About
Matthew Troese is from Allentown, Pennsylvania, United States. Matthew works in the following industries: "Research Services". Matthew is currently Development Scientist at VaxForm. In Matthew's previous role as a Study Director at MB Research Laboratories, Matthew worked in Allentown, Pennsylvania Area until Jun 2021. Prior to joining MB Research Laboratories, Matthew was a Postdoctoral Fellow at VCU and held the position of Postdoctoral Fellow at Richmond, Virginia Area. Prior to that, Matthew was a Graduate Student at UK & VCU from Aug 2005 to Dec 2010.
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Matthew Troese's current jobs
Research and Development of Vaccine production and stability.
Matthew Troese's past jobs
Study Director with the responsibility of conducting in vitro toxicology in a GLP laboratory. Main areas of experience include Pre-Clinical evaluation of in vitro skin irritation, skin corrosion and skin sensitization using both 3D tissue models and cell lines. Aid in the development and validation of new assays, including newly developed company assays and OECD regulatory approved assays. Actively working towards the development of new in vivo and in vitro toxicology assays. I have been awarded 3 grants totaling $482,783 in funding in the areas of skin sensitization and photogenotoxicity.
Studied the molecular pathogenesis of the obligate intracellular, tick-transmitted pathogen, Anaplasma phagocytophilum. Identified surface proteins that could be studied as potential vaccine targets.
Characterization and elucidation of the molecular pathogenesis of the obligate intracellular, tick-transmitted and potentially fatal human pathogen, Anaplasma phagocytophilum (BSL-2). Designed, implemented and troubleshoot new and existing experimental methods to test hypotheses. Research areas focused on pathogen-host cells interactions. Research was focused in several main areas of study: (1) Identify A. phagocytophilum adhesin(s) adhering to glycoprotein (PSGL-1) expressed on neutrophils. Biotinylation led to identification of first infectious form specific marker. (2) Modification of A. phagocytophilum Msp2 (P44), the bacterium’s major surface protein. (3) Elucidate intracellular survival strategies of A. phagocytophilum. Identified first two bacterial-derived Anaplasma-occupied vacuolar membrane (AVM) proteins.