Megha Verma
About
Megha Verma is from Philadelphia, Pennsylvania, United States. Megha works in the following industries: "Research Services". Megha is currently Senior Scientist at Ocugen, located in Malvern, Pennsylvania, United States. Megha also works as Co-Founder and Editor-in-Chief at Postdoc Scientific Editing and Reviewing Team (PSERT), Thomas Jefferson University, a job Megha has held since May 2018. In Megha's previous role as a Postdoctoral Researcher at Johnson & Johnson, Megha worked in until Oct 2021. Prior to joining Johnson & Johnson, Megha was a CAR-T Scientist at Eurofins Lancaster Laboratories and held the position of CAR-T Scientist at Spring House, Pennsylvania. Prior to that, Megha was a Postdoctoral Research Fellow at Thomas Jefferson University, based in Greater Philadelphia Area from Aug 2015 to Sep 2018. Megha started working as Vice President for Career Development at Thomas Jefferson University in Greater Philadelphia Area in Jun 2017. From Jun 2016 to Jun 2017, Megha was Secretary for Jefferson Postdoctoral Association at Thomas Jefferson University, based in Greater Philadelphia Area. Prior to that, Megha was a Ph.D. at Roskamp Institute, based in Roskamp Institute from May 2012 to Jul 2015. Megha started working as Research Assistant at University of Nottingham in United Kingdom in Jul 2010.
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Megha Verma's current jobs
The purpose of PSERT is to help postdocs improve editing, reviewing, and writing skills as we train together and practice those skills.
Megha Verma's past jobs
Studying the epigenetic basis of early-life lead exposure in rats and effects on brain development and cognition. • Examining the influence of genetic background (i.e. strain) on Lead-induced behavioral and molecular deficits in a rodent model of neurotoxicity. • Investigating the effect of developmental Lead (Pb) exposure on methylation of genes involved in learning and memory in male and female rodent model of neurotoxicity. • Confirmed the role of genetic background in modulating the neurobehavioral outcome post lead (Pb) exposure in different strain of rats. • Testing various pharmacological agents to determine the reversal of DNA methylation on impaired learning and memory related genes.
Project entitled : Impact of nicotinic acetylcholine receptors signaling pathways in mouse models of Alzheimer’s disease. In this study, we investigated the impact of anatabine on pathological Aβ deposition, neuroinflammation and behavioral deficits in a transgenic mouse model of AD (Tg PS1/APPswe). The results of our study show that treatment with anatabine improves memory deficits, social interaction and social memory in Tg PS1/APPswe mice and also reduces hyperactivity and disinhibition which affect various mouse models of AD-overexpressing Aβ and reduces inflammation and Aβ load.
Project entitled: Limbal Stem Cell (LSC) isolation and characterisation for ex vivo transplantation • Worked on “limbal stem cells isolation and their characterization for ex vivo transplantation” • Isolation of corneal stem cells using novel surface biomarkers by FACS (Mo Flo and Altra Flow) and to test the “stem - ness” using assays like colony forming efficiency, clonal expansion and validation with Real Time-qPCR, TaqMan Probe efficiency testing and selection of endogenous gene using geNorm software • Frozen tissue section preparation, Immunostaining, and Immunofluorescence • Eye retrieval from deceased person consented for donation including training students and staff • Amnion contest and processing for its use as feeder layers for stem cells growth and expansion • Assisting and guiding medical student projects, and summer research experience students in laboratory • Writing SOP, and COSHH, waste management, external orders project fund management and lab induction • Poster presentation: “Gene profiling of explants culture and corneal epithelial cell line” at Nottingham Eye Symposium, East Midlands Centre, Nottingham
Project entitiled: Dysregulation of calcium influx in breast cancer Accomplishments and roles: • Showed Annexin II is required for S100A10 Ca2+ dependent translocation to cell membrane in normal human bronchial cells by ectopic expression of plasmid containing Annexin II and S100A10 using Confocal Microscopy (Zeiss LSM 510) • Live cell & calcium confocal microscopy imaging, DNA cloning, western blot, mammalian cell culture and RT-qPCR • Lab maintenance and preparing of stock solutions, SOP writing, waste disposal and COSHH Report writing, and results presentation • Technical Assistance to member of staff, master’s students in various experiments in Dr Muimo’s Lab