Paul James Rothwell
About
Paul James Rothwell is from London, England, United Kingdom. Paul James works in the following industries: "Research Services". Paul James is currently Vice President, Platform Research at Touchlight Genetics Ltd. In Paul James's previous role as a Director of Platform Research at Touchlight Genetics Ltd, Paul James worked in London, United Kingdom until Feb 2020. Prior to joining Touchlight Genetics Ltd, Paul James was a Group Leader Innovations at Touchlight Genetics Ltd. and held the position of Group Leader Innovations at Hampton. Prior to that, Paul James was a Group Leader Core technologies at Touchlight Genetics Ltd., based in Leatherhead from Jan 2014 to Jan 2015. Paul James started working as Senior Research Scientist at TOUCHLIGHT GENETICS LIMITED in leatherhead in Jan 2012. From Jan 2007 to Jan 2011, Paul James was EXPERIENCED RESEARCH SCIENTIST (EUROPEAN UNION) at Institute of Molecular Physical Chemistry, HHU , Düsseldorf, Germany, based in Düsseldorf Area, Germany. Prior to that, Paul James was a Wellcome fellowship at Institute of Structural Molecular Biology, UCL/Birkbeck, London, United Kingdom, based in London U.K from Jun 2003 to Dec 2006. Paul James started working as Post-Doctoral Position at Max-Planck-Institute for Molecular Physiology in Dortmund Area, Germany in Jul 2002.
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Paul James Rothwell's current jobs
Paul James Rothwell's past jobs
Providing strategic leadership of the platform research department managing DNA molecular architecture, process innovations, process transfer, protein evolution, and protein purification. .
Overseeing group operations for a progressive organisation dedicated to developing revolutionary new DNA products. Creating new technologies, processes, and intellectual property. Optimised high-yielding expression systems for Phi29 DNA polymerase and 7 protelomerases. directing five Innovations research scientists in all research-related activities while mentoring and leading scientists within platform development and protein related activities. Engaging with a diverse group of stakeholders and groups as a member of the scientific team. Key Accomplishments: • Realised significant cost savings by developing the highest yield in vitro DNA amplification process while implementing innovative and simplified processes to improve nucleic acid amplification. • Implemented a fully in vitro process for construction and amplification of DNA constructs and libraries • co-inventor on nine patents in the areas of DNA production, yield enhancement, process control, and, in vitro gene construction.
Provided technical and staff leadership while maintaining focus on achieving core objectives and goals. Nurtured and encouraged team ingenuity and creativity during the development of an innovative platform solution. Ensured strict alignment with departmental guidelines, policies, and procedures. Key Accomplishments: • Conceptualised and created Touchlights’ first platform to produce in vitro DNA which was then adopted and used in the manufacture of DNA products. • Created and implemented purification procedures for main process enzymes transferred to CMO.
Leveraged expertise in DNA and DNA binding proteins to successfully lead research and development efforts. Key Accomplishments: • Improved the process for producing and purifying therapeutic DNA by spearheading the creation of a single temperature column free process. • Enforced and maintained impeccable standards throughout all phases of process development.
• Managed a team of 8 scientists working towards BSc through to post-doctorate level throughout the completion of protein biochemistry projects. • Worked within a key pan European project responding to questions on DNA enzymes funded through the EU framework grant "DNA enzymes". • Contributed towards a portfolio of projects including DNA polymerases (Klentaq, Klenow, HIV-1 RT), DNA repair enzymes (UVR, MutS) and ABC transporters (OPP). • Supported several protein purification projects from outside the department demonstrating expertise in the area.
• Completing a Wellcome Fellowship, taking a leading role in the acquisition, installation, and end user training on equipment for a new biophysics laboratory. • Utilising Biophysical techniques to resolve one of the longest standing debates regarding DNA polymerase action.
• Developing a FRET based assay to study dimerisation kinetics of HIV-1 reverse transcriptase