Raghu V

Led technical oversight and management of GMP manufacturing and validation activities for proprietary lipids and small molecules, ensuring compliance with regulatory standards and internal quality systems throughout the product lifecycle. Managed relationships with CMOs and CROs, driving effective collaboration across EMSC, Quality, and Analytical Development teams. Provided technical input and leveraged process data to support informed decision-making and timely resolution of manufacturing challenges. Planned and executed Process Performance Qualification (PPQ) and process characterization studies in partnership with internal and external stakeholders, ensuring robust process understanding and regulatory readiness. Assessed feasibility of novel synthesis approaches and processing steps. Led and drove process development projects and evaluation of emerging technologies, maturing manufacturing processes and implementing changes through formal change control. Authored and reviewed risk assessments, technical reports, batch records, specifications, analytical methods, and supporting regulatory documents in alignment with GMP requirements.

• Designed and evaluated the synthetic compounds that lead to the degradation (“PROTACS”) of histone acetyltransferase enzymes and their utility as potential cancer therapeutics. • Developed a most robust synthetic strategy to diversify the CRBN binding analogs with structural diversity and used in phenotypic assays for identification of new neo-substrates.

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• Successfully managed multiple research projects by strategically planning and prioritizing tasks to study tetrazine ligation for PET imaging applications resulting in the preparation of a patent and a manuscript. • Demonstrated exceptional interpersonal skills by initiating and managing collaborations amongst diverse bench scientists (biochemists, microbiologists) to complete goals on time • Well-developed self-motivation, organization and project management skills that pursue parallel independent research paths and publish as corresponding author

• Managed and participated in 6 independent research projects with collaborations to study the biochemical pathways involved in septanoses in lectins, resulting 8 peer-reviewed publications and attendance at 3 international conferences. • Developed synthetic methods and studied unnatural seven membered ring sugars (septanosides) as E. coli fimbrial adhesion (fimH) inhibitors • Proficiently communicated and presented complex scientific concepts by mentoring 4 under graduate students that helped them to choose science as their careers • Served as laboratory safety enforcer, implementing safety procedures, and ensuring all group members followed safe laboratory work practices

• Conducted laboratory experiments with undergraduate students in organic chemistry course • Mentored undergraduate students in a laboratory setting

• Developed and synthesized chiral vinylphosphine boranes up to 200g to support chemical development department internally

• Synthesized chiral sulfilimines as intramolecular nucleophiles and applied towards the synthesis of Castanospermine, and Solandelactone-F