Roshan Liyanage Ph D
About
Roshan Liyanage Ph D is from San Francisco, California, United States. Roshan works in the following industries: "Biotechnology Research". Roshan is currently Associate Director, Analytical Development at Vaxcyte, located in San Francisco Bay Area. Roshan also works as Chair - Biotechnology Advisory Board at Shoreline Community College, a job Roshan has held since Feb 2018. In Roshan's previous role as a Group Leader, Analytical Lifecycle Management at Partner Therapeutics, Roshan worked in Greater Seattle Area until Oct 2021. Prior to joining Partner Therapeutics, Roshan was a Scientist II at Bristol-Myers Squibb and held the position of Scientist II at Greater Seattle Area. Prior to that, Roshan was a Quality Control In-Charge at Inventprise LLC, based in Greater Seattle Area from Jun 2016 to Feb 2017. Roshan started working as Staff Scientist at ArmaGen Technologies in Greater Los Angeles Area in Apr 2015. From Dec 2010 to Apr 2015, Roshan was Scientist/Group Leader, Formulation and Assay Support Group at Dendreon. Prior to that, Roshan was a Postdoctoral Researcher at Macromolecule and Vaccine Stabilization Center from May 2009 to Dec 2010. Roshan started working as Graduate Research Assistant at University of Kansas in Jan 2004.
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Roshan Liyanage Ph D's current jobs
Roshan Liyanage Ph D's past jobs
• Lead formulation development activities by planning, prioritization, and execution of stability studies, buffer and excipient screening, container/closure compatibility and fill/finish studies. These studies include identifying degradation pathways, employing DOE (SAS JMP) for buffer and excipient screening, investigating impact of buffer component on assay performance, and particle size characterization (MFI). • Involved in development and characterization of aseptic and UF/DF filtration processes for formulation changes. • Participated in commercial activities by providing assay support for the reference material qualification process, participating QC - Analytical Sciences monthly meeting as a technical expert, and by providing assay support and analytical expertise to OOT/OOS investigations at CMO sites, and respond to FDA inquiries. • Provided analytical expertise and assay support for process changes, process characterization, and material qualification for commercial activities. • Authored, and reviewed technical reports and SOPs and contributed to the CMC sections of regulatory submissions. Experience with quality management systems and method life cycle management. • Lead analytical activities for process development of commercial and pipeline products, including planning, prioritization, and execution of experiments. The activities include titer, residual, and host cell protein analysis of process intermediates from both upstream and downstream process development by SDS-PAGE, Western blot analysis, HPLC (SEC and RP), CE (Caliper), ELISA, and Fortebio Octet. • Developed, qualified, and executed characterization, release and stability assays for drug substance and drug products. These assays include HPLC (RP, SEC, and AEX), SDS-PAGE, DSC, CD, peptide maps, and glycan profiling.
• Performed biophysical characterization of recombinant proteins for vaccine development using Fluorescence, CD, FTIR, DSC, AUC, cIEF, DLS, particle size characterization (MFI), Peptide map analysis, and mass spectrometry. • Performed lyophilization cycle development for stable vaccine development. • Performed stability indicating assay development, buffer, pH, ionic strength, and excipients screening for preformulation of vaccine candidates. • Authored technical reports and presented project updates to external project stake holders to communicate the formulation development activities. • Trained and mentored technical staffs, graduate students, and postdocs for instruments usage, assay development, and formulation development duties.
• Developed assays for protein-ligand interactions, protein modification analysis, protein dynamics monitoring using RP-HPLC, fluorescence polarization, fluorescence lifetime, and fluorescence resonance energy transfer techniques. • Performed protein analysis using CE and microchip based CE techniques. • Performed recombinant protein expression in microbial systems and protein purification using numerous chromatographic methods including affinity, AEX, and SEC. • Performed protein labeling with fluorescence tags using specific conjugation chemistries and evaluated impact of dye-protein interactions on fluorescence measurements