Silas Wood
About
Silas Wood is from Denver, Colorado, United States. Silas works in the following industries: "Biotechnology Research". Silas is currently Scientist II at Greffex, Inc., located in Aurora, Colorado, United States. In Silas's previous role as a Research Intern at Greffex, Inc., Silas worked in Aurora, Colorado, United States until Jan 2022. Prior to joining Greffex, Inc., Silas was a Masters Student at University of Colorado Anschutz Medical Campus and held the position of Masters Student at Denver, Colorado, United States. Prior to that, Silas was a Graduate Student at University of Colorado Anschutz Medical Campus, based in Aurora, CO from Aug 2017 to Dec 2020. Silas started working as Research Assistant at Truman State University in Kirksville, Missouri in Dec 2016.
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Silas Wood's current jobs
Silas Wood's past jobs
The efficacy of current influenza vaccines is limited by frequent immune-evading mutations in the head domain of hemagglutinin, the influenza cell-surface receptor responsible for host cell entry and infection. Novel vaccine formulations that direct the immune response towards the conserved hemagglutinin stem domain by utilizing truncated hemagglutinin constructs may represent the first step towards universal influenza vaccines. At Greffex, we are developing next-generation influenza vaccines using hemagglutinin stem constructs designed to target both currently circulating influenza strains, as well as strains with future pandemic potential. My project centers around the design, expression, and purification of soluble forms of several of our hemagglutinin stem constructs for structural characterization using X-ray crystallography and cryo-electron microscopy. Skills: -Molecular cloning -DNA purification -Cell culture -Protein expression and purification -Project management -Laboratory management
Masters student in the Biomedical Science and Biotechnology (BSBT) program.
Ph.D. Candidate in the Structural Biology and Biochemistry (STBB) Program at CU Anschutz in the lab of Dr. Maggie Lam. In Dr. Lam's lab, my research was focused on using mass spectrometry and computational techniques to probe early proteomic responses to anthracycline chemotherapeutics in the heart. My work in Dr. Lam's lab involved a variety of biochemical and computational techniques, including cell tissue culture, isolating and preparing complex protein samples for mass spectrometry analysis, and analyzing large datasets using R and Python. Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart. Dostal V, Wood SD, Thomas CT, Han Y, Lau E, Lam MPY. Sci Rep. 2020 Oct 28;10(1):18440. doi: 10.1038/s41598-020-75505-8. PMID: 33116222; PMCID: PMC7595225. Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart. Han Y, Wood SD, Wright JM, Dostal V, Lau E, Lam MPY. J Mol Cell Cardiol. 2021 Feb 4:S0022-2828(21)00024-9. doi: 10.1016/j.yjmcc.2021.01.007. Epub ahead of print. PMID: 33549679.
Worked as a research assistant in the lab of Dr. Bill Miller III, whose lab focuses on using molecular dynamics simulations to probe complex chemical and biomolecular interactions. In Dr. Miller's lab, I helped to develop and run molecular dynamics simulations of novel bacterial ligand-receptor interactions using the AmberMD software suite in Linux.