Soumili Chattopadhyay
About
Soumili Chattopadhyay is from San Francisco Bay Area. Soumili works in the following industries: "Biotechnology Research". Soumili is currently Associate Scientist II at Vaxcyte, located in San Francisco Bay Area. In Soumili's previous role as a Research Executive at Pfizer, Soumili worked in Chennai, Tamil Nadu, India until Feb 2019. Prior to joining Pfizer, Soumili was a Research Associate at IIT Delhi and held the position of Research Associate at India.
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Soumili Chattopadhyay's current jobs
I am working in Formulation Development and Drug Product Analytics group at Vaxcyte. We are working on protein-polysaccharide conjugate vaccines against pneumococcal disease. - Pre-formulation studies for multi-valent adjuvanted vaccine against pneumonia including optimization of formulation buffer based on a DoE approach, in-vivo studies and sub-visible particle characterization - Supporting analytical activities for early-stage IND enabling stability studies for 24 drug substances and lead/backup formulations at different conditions - Method development for drug product analytics such as tools characterizing particle size and settling velocity - DP process development activities: Filter selection, adjuvant and drug substance mixing parameters, fill-finish processing for at-scale manufacturing
Soumili Chattopadhyay's past jobs
Worked on following biosimilar mAb projects at Pfizer: 1. Analytical method development for determination of identity and sequence modification in IgG1 monoclonal antibody (mAb) 2. Analytical method development for determination of charge variants and size-heterogeneity for mAbs using imaged Capillary Electrophoresis (cIEF / CE-SDS) 3. Formulation development of mAbs for conformational and colloidal stability using biophysical techniques. Technical skills developed: • Preparative Chromatography - Protein-A, Multi-modal (MMC), Cation Exchange (CEX), Weak Anion Exchange, Ni-NTA based purification of His-tagged proteins • Analytical Chromatography - Reversed-Phase (RP), Size-Exclusion (SEC), Hydrophilic liquid interaction (HILIC), Ion-Exclusion chromatography • Biophysical techniques: Florescence spectroscopy, Differential scanning calorimetry (DSC), Dynamic light scattering (DLS), Circular Dichroism (CD), HIAC Liquid Particle Counter, Micro-Flow Imaging (MFI) • Computational: JMP statistical tool, MATLAB, • Electronic Lab Notebook (eLN), LIMS Awards received - • Recipient of Pfizer awards for performance – ‘Employee of the Month’ (2018) • Recipient of internal Pfizer awards under OwnIt! category: ‘Impact Results’ and ‘Own the Business’
Research Area: Analytical method development for biologics Worked on developing a two high performance liquid chromatography (HPLC) based methods for direct and simultaneous estimation of excipients in biopharmaceutical products. Published papers - 1. Hebbi, V., Chattopadhyay, S., & Rathore, A. S. (2019). High performance liquid chromatography (HPLC) based direct and simultaneous estimation of excipients in biopharmaceutical products. Journal of Chromatography B, 1117, 118-126. 2. Bansal R, Chattopadhyay S, Maurya GP, Haridas V, Rathore AS. Peptide Dendrons as Thermal-Stability Amplifiers for Immunoglobulin G1 Monoclonal Antibody Biotherapeutics. Bioconjug Chem. 2017 Oct 18;28(10):2549-2559. doi: 10.1021/acs.bioconjchem.7b00389. Epub 2017 Sep 28. PMID: 28880521. 3. Patent: A formulation for stabilizing bio-therapeutics