Jack Gengcheng Yang

Your express of research and development, manufacturing and commercialization.

Fight against infectious diseases using state-of-the-art medicinal chemistry and biopharmaceuticals by therapeutic mAbs and vaccinal large molecules, nanoparticals and protein-antigen conjugates. Good at quantifying residual low content of small molecules in protein samples, including but not limited to viral inactivation organics, cell transfection additives, fatty acids, PS-80, PF-68 and sugar alcohols by either GC or LC techniques. Expert at amino acid analysis, glycosylation path way tracing, oligosaccharide profiling and quantitation, MS peptide mapping to support mAb, carrier protein-peptide conjugates, linker design and optimization for ADC development. Versed in GMP/cGMP/GLP drug developmental environment. Experienced writer of SOP/DOP, analytical reports, manuscripts, SOP, IND and BLA for filing.

At MedImmune/AstraZeneca in Gaithersburg, MD, USA. Research scientist in the Product Variant Characterization Group to assist IND and BLA filing. Proficient in protein degradation pathways investigation using HPLC and LC-MS via stress studies ( photo, thermal and chemical stress, pH and serum incubation stress). Expert at carbohydrate analysis and method development for mAb glycan quantification by peptide mapping and intact mass analysis with LC-MS, 2-AB oligosaccharide profiling, sialic acid and 2-AA monosaccharide quantitation. Expert at SEC, IEC, HIC, RP, HILIC, Affinity chromatography and cIEF, GXII analysis of protein samples, as well as method development, qualification and validation. Proficient in micro-scale protein purification from serum for PK/PD studies to support clinical studies.

R&D in drug discovery and flavor science based on Chromovert technology. Structure-Property-Relationship investigation based on experience in medicinal chemistry and drug discovery. Inventor of compounds and methods for modulation the sweet taste of beverages (Patent US 20150050410A1)

Overlooked and managed projects in collaboration with overseas CRO and CMO. In the department of Advanced Analytical Technology, supporting product release by timely analysis of impurities in J&J's Health Care Products. Successfully prepared grams of several cortisol derivatives present in Cortaid(TM) within a short time.

Setting up the Monmouth Junction research facility sponsored by Hengrui Pharmaceuticals. Oncology drug discovery based on patents and publications.

Medicinal Chemist expertized in the charaterization, purification and syntheses of a variety of drug-like compounds for projects from lead discovery to lead optimization in the Exploratory Medicinal Chemistry Department.

Hit-to-lead and lead optimization in a variety of drug discovery programs, leading to several drug candidates proceeding forward to development discovery, or/and helped making no-go decisions based on knowledge obtained by the exploration of SAR&SPR.

09/16/2002―09/2003 PTC Therapeutics, Inc. South Plainfield, New Jersey · Syntheses of a series of stereo-specific nucleoside analogs in lead optimization of an anti-cancerous project via mRNA regulation with nonsense suppression active small molecules. Syntheses of thiophenes, benzothiophenes, and furopyridine derivatives for the lead discovery in an anti-viral HCV project. Large-scale preparation of cystic fibrosis drug candidate (PTC-124) for PK study.

Solid phase RNA synthesis; Nucleoside, nucleotide, oligonucleotide, phosphoramidites and DNA/RNA chimera syntheses; heterocyclic compounds, HPLC, NMR and LC MS, teaching organic chemistry labs.

Group leader, Project team leader for 9-5 Gongguan Project Expertised in the radiation chemistry of organic compounds, organic polymers and composites. Excellent Young Research Fellow, Academia Sinica, Lanzhou, 1994. Outstanding Research Fellow in "9-5 Gongguan project", Academia Sinica, Beijing, 1996. Major inventor of 4 industrial patents. Co-inventor of 3 industrial patents.